里昂（讓·雷諾飾）是名孤獨(dú)的職業(yè)殺手，受人雇傭。一天，鄰居家小姑娘馬蒂爾達(dá)（納塔麗·波特曼飾)敲開他的房門，要求在他那里暫避殺身之禍。原來鄰居家的主人是警方緝毒組的眼線，只因貪污了一小包毒品而遭惡警（加里·奧德曼飾）殺害全家的懲罰。馬蒂爾達(dá)得到里昂的留救，幸免于難，并留在里昂那里。里昂教小女孩使槍，她教里昂法文，兩人關(guān)系日趨親密，相處融洽。 女孩想著去報(bào)仇，反倒被抓，里昂及時(shí)趕到，將女孩救回?；祀s著哀怨情仇的正邪之戰(zhàn)漸次升級，更大的沖突在所難免……
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